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Palladium-Catalyzed Intramolecular Cyclization of 2-Iodobenzamides: An Efficient Synthesis of 3-Acyl Isoindolin-1-ones and 3-Hydroxy-3-acylisoindolin-1-ones

Wanli Chen*, Lina Jin, Yinghong Zhu*, Xiaoji Cao, Lebin Zheng, Weimin Mo

*Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: chenwlzjut.edu.cn, yhzhuchemzjut.edu.cn

W. Chen, L. Jin, Y. Zhu, X. Cao, L. Zheng, W. Mo, Synlett, 2013, 24, 1856-1860.

DOI: 10.1055/s-0033-1339449


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Abstract

An efficient palladium-catalyzed intramolecular cyclization of 2-iodobenzamides with a 2-oxoethyl function group on the nitrogen atom moiety provides 3-acyl isoindolin-1-ones and 3-hydroxy-3-acylisoindolin-1-ones under mild conditions in good yields.

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Key Words

intramolecular cyclization, palladium catalysis, 3-acyl isoindolin-1-ones, 3-hydroxy-3-acylisoindolin-1-ones, Isoindolinones, 2-iodobenzamides


ID: J60-Y2013