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Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives

Anthony R. Mazzotti, Michael G. Campbell, Pingping Tang, Jennifer M. Murphy and Tobias Ritter*

*Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States, Email: ritterchemistry.harvard.edu

A. R. Mazzotti, M. G. Campbell, P. Tang, J. M. Murphy, T. Ritter, J. Am. Chem. Soc., 2013, 135, 14012-14015.

DOI: 10.1021/ja405919z (free Supporting Information)


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Abstract

A palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway that involves a Pd(III) intermediate.

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Key Words

Fluoroarenes, Selectfluor


ID: J48-Y2013