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Palladium-Catalyzed Methylation of Alkynyl C(sp)-H Bonds with Dimethyl Sulfonium Ylides

Yan-Yun Liu, Xu-Heng Yang, Xiao-Cheng Huang, Wen-Ting Wei, Ren-Jie Song and Jin-Heng Li*

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email: jhlihnu.edu.cn

Y.-Y. Liu, X.-H. Yang, X.-C. Huang, W.-T. Wei, R.-J. Song, J.-H. Li, J. Org. Chem., 2013, 78, 10421-10426.

DOI: 10.1021/jo401851m (free Supporting Information)


Abstract

Sulfonium ylides can be used as alkyl electrophiles in a palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes via a C(sp)-C(sp3) bond formation process.

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Key Words

Alkynes


ID: J42-Y2013