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Palladacycle-Catalyzed Deacetonative Sonogashira Coupling of Aryl Propargyl Alcohols with Aryl Chlorides

Hao Hu, Fan Yang* and Yangjie Wu*

*The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, People’s Republic of China, Email: yangfzzu.edu.cn, wyjzzu.edu.cn

H. Hu, F. Yang, Y. Wu, J. Org. Chem., 2013, 78, 10506-10507.

DOI: 10.1021/jo4014657 (free Supporting Information)


Abstract

An efficient and general protocol for the deacetonative Sonogashira coupling of aryl propargyl alcohols with aryl chlorides proceeded smoothly in the presence of a palladacycle and Xphos. The method enables a deacetonative Sonogashira coupling of electron-poor, electron-neutral, and even inactive sterically hindered electron-rich aryl chlorides.

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Key Words

Sonogashira Coupling


ID: J42-Y2013