Palladacycle-Catalyzed Deacetonative Sonogashira Coupling of Aryl Propargyl Alcohols with Aryl Chlorides
Hao Hu, Fan Yang* and Yangjie Wu*
*The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, People's Republic of China, Email: yangfzzu.edu.cn, wyjzzu.edu.cn
H. Hu, F. Yang, Y. Wu, J. Org. Chem., 2013, 78, 10506-10507.
DOI: 10.1021/jo4014657
Abstract
An efficient and general protocol for the deacetonative Sonogashira coupling of aryl propargyl alcohols with aryl chlorides proceeded smoothly in the presence of a palladacycle and Xphos. The method enables a deacetonative Sonogashira coupling of electron-poor, electron-neutral, and even inactive sterically hindered electron-rich aryl chlorides.
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ID: J42-Y2013