One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles
Guolin Zhang*, Hangcheng Ni, Wenteng Chen, Jiaan Shao, Huan Liu, Binhui Chen and Yongping Yu*
*Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, P. R. China, Email: yyuzju.edu.cn, guolinzhangzju.edu.cn
G. Zhang, H. Ni, W. Chen, J. Shao, H. Liu, B. Chen, Y. Yu, Org. Lett., 2013, 15, 5967-5969.
DOI: 10.1021/ol402810f
Abstract
A simple and straightforward multicomponent reaction of vinyl azide, aldehyde, and tosylhydrazine affords 3,4,5-trisubstituted 1H-pyrazoles regioselectively in good yields in the presence of a base. The reaction tolerates a range of functional groups.
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Key Words
pyrazoles, multicomponent reactions
ID: J54-Y2013