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Indium(III)-Catalyzed One-Pot Synthesis of Alkyl Cyanides from Carboxylic Acids

Toshimitsu Moriya, Kohei Shoji, Shinichiro Yoneda, Reiko Ikeda, Takeo Konakahara, Norio Sakai*

*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan, Email: sakachemrs.noda.tus.ac.jp

T. Moriya, K. Shoji, S. Yoneda, R. Ikeda, T. Konakahara, N. Sakai, Synthesis, 2013, 45, 3233-3238.

DOI: 10.1055/s-0033-1339903 (free Supporting Information)


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Abstract

Indium(III)-catalyzed reductive iodination or bromination of carboxylic acids enables a one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides.

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Indium-Catalyzed Reductive Bromination of Carboxylic Acids Leading to Alkyl Bromides

T. Moriya, S. Yoneda, K. Kawana, R. Ikeda, T. Konakahara, N. Sakai, Org. Lett., 2012, 14, 4842-4845.


Key Words

indium, TMDS, deoxygenation, halogenation, carboxylic acids, nitriles


ID: J66-Y2013