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Metal-Free Synthesis of Aryl Ethers in Water

Erik Lindstedt, Raju Ghosh and Berit Olofsson*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden, Email: beritorgan.su.se

E. Lindstedt, R. Ghosh, B. Olofsson, Org. Lett., 2013, 15, 6070-6073.

DOI: 10.1021/ol402960f (free Supporting Information)


Abstract

An arylation of allylic and benzylic alcohols with diaryliodonium salts yields alkyl aryl ethers under mild and metal-free conditions. Phenols are arylated to diaryl ethers in good to excellent yields. The reaction employs diaryliodonium salts and sodium hydroxide in water at low temperature, and avoids the use of excess amounts of the coupling partners.

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Mild Synthesis of Sterically Congested Alkyl Aryl Ethers

E. Lindstedt, E. Stridfeldt, B. Olofsson, Org. Lett., 2016, 18, 4234-4237.


Key Words

aryl ethers, diaryl ethers, green chemistry


ID: J54-Y2013