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Conversion of Pyridine to Imidazo[1,2-a]pyridines by Copper-Catalyzed Aerobic Dehydrogenative Cyclization with Oxime Esters

Huawen Huang, Xiaochen Ji, Xiaodong Tang, Min Zhang, Xianwei Li and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: jianghfscut.edu.cn

H. Huang, X. Ji, X. Tang, M. Zhang, X. Li, H. Jiang, Org. Lett., 2013, 15, 6218-6221.

DOI: 10.1021/ol403105p (free Supporting Information)



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Abstract

A rapid, copper-catalyzed aerobic dehydrogenative cyclization of pyridines with ketone oxime esters enables an environmentally friendly synthesis of imidazo[1,2-a]pyridines.

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Key Words

imidazo[1,2-a]pyridines, oxygen


ID: J54-Y2013