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I2-Catalyzed Synthesis of Substituted Pyrroles from α-Amino Carbonyl Compounds and Aldehydes

Rulong Yan*, Xing Kang, Xiaoqiang Zhou, Xiaoni Li, Xingxing Liu, Likui Xiang, Yamin Li and Guosheng Huang*

*State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, China, Email: yanrllzu.edu.cn, hgslzu.edu.cn

R. Yan, X. Kang, X. Zhou, X. Li, X. Liu, L. Xiang, Y. Li, G. Huang, J. Org. Chem., 2014, 79, 465-470.

DOI: 10.1021/jo402620z (free Supporting Information)


Abstract

A cyclization of α-amino carbonyl compounds and aldehydes catalyzed by I2 enables a synthesis of 1,3,4-triarylpyrroles. This reaction proceeds smoothly in good yields and tolerates various functional groups.

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Key Words

Pyrroles


ID: J42-Y2014