Clean and Economic Synthesis of Alkanesulfonyl Chlorides from S-Alkyl Isothiourea Salts via Bleach Oxidative Chlorosulfonation
Zhanhui Yang, Bingnan Zhou, Jiaxi Xu*
*State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, P. R. of China, Email: jxxumail.buct.edu.cn
Z. Yang, B. Zhou, J. Xu, Synthesis, 2014, 46, 225-229.
DOI: 10.1055/s-0033-1338567 (free Supporting Information)
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A clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is simple, environment- and worker-friendly. The procedure uses readily accessible reagents, offers safe operations and easy purification without chromatography, and affords high yields.
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Z. Yang, J. Xu, Synthesis, 2013, 45, 1675-1682.
Z. Yang, Y. Zheng, J. Xu, Synlett, 2013, 24, 2165-2169.