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Three-Component Reaction between Alkynes, Elemental Sulfur, and Aliphatic Amines: A General, Straightforward, and Atom Economical Approach to Thioamides

Thanh Binh Nguyen*, Minh Quan Tran, Ludmila Ermolenko and Ali Al-Mourabit

*Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France, Email: nguyenicsn.cnrs-gif.fr

T. B. Nguyen, M. Q. Tran, L. Ermolenko, A. Al-Mourabit, Org. Lett., 2014, 16, 310-313.

DOI: 10.1021/ol403345e (free Supporting Information)


Abstract

A three-component reaction of alkynes, elemental sulfur, and aliphatic amines allows a general, straightforward, and atom-economical synthesis of thioamides.

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Key Words

Thiolation, Hydroamination, Multicomponent Reactions


ID: J54-Y2014