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Palladium-Catalyzed Acetylation of Arenes

Stephen D. Ramgren and Neil K. Garg *

*Department of Chemistry and Biochemistry University of California, Los Angeles, California 90095-1569, United States, Email: neilgargchem.ucla.edu

S. D. Ramgren, N. K. Garg, Org. Lett., 2014, 16, 824-827.

DOI: 10.1021/ol403570z (free Supporting Information)


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Abstract

A simple method for the preparation of aryl methyl ketones involves the Pd-catalyzed coupling of commercially available acetyltrimethylsilane with aryl bromides to afford the corresponding acetylated arenes in very good yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization.

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Key Words

acylations, Hiyama Coupling


ID: J54-Y2014