Ruthenium-Catalyzed Hydroarylation of Anilides with Alkynes: An Efficient Route to Ortho-Alkenylated Anilines
Rajendran Manikandan and Masilamani Jeganmohan*
*Department of Chemistry, Indian Institute of Science
Education and Research, Pune 411021, India, Email: mjeganmohan
iiserpune.ac.in
R. Manikandan, M. Jeganmohan, Org. Lett., 2014, 16, 912-915.
DOI: 10.1021/ol403666s
Abstract
The reaction of acetanilides with symmetrical as well as unsymmetrical alkynes in the presence of [{RuCl2(p-cymene)}2], pivalic acid, and AgSbF6 in i-PrOH provides ortho-alkenylated acetanilides in a highly regio- and stereoselective manner. The products can be converted into ortho-alkenylated anilines in the presence of HCl.
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Key Words
ID: J54-Y2014
