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A Microwave-Assisted Three-Component Synthesis of Arylaminomethyl Acetylenes: A Facile Access to Terminal Alkynes

Yubo Jiang*, Shaojun Huang

*Faculty of Science, Kunming University of Science and Technology, Kunming 650500, P. R. of China, Email: ybjiangkmust.edu.cn

Y. Jiang, S. Huang, Synlett, 2014, 25, 407-410.

DOI: 10.1055/s-0033-1340331 (free Supporting Information)


Abstract

Microwave-assisted conditions enabled a simple, rapid, one-pot synthesis of arylaminomethyl acetylenes in very good yields using arylboronic acids, aqueous ammonia, propargyl halides, copper(I) oxide and water as the solvent within ten minutes.


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Key Words

Chan-Lam coupling, microwave synthesis, multicomponent reactions, ammonia, propargyl halide, propargyl amines, aryl amines, terminal alkynes


ID: J60-Y2014