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Unmasked Acyl Anion Equivalent from Acid Chloride with Indium: Reversed-Polarity Synthesis of Unsymmetric Aryl Aryl and Alkenyl Aryl Ketone through Palladium-Catalyzed Cross-Coupling Reaction

Dohyung Lee, Taekyu Ryu, Youngchul Park and Phil Ho Lee*

*Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea, Email: phleekangwon.ac.kr

D. Lee, T. Ryu, Y. Park, P. H. Lee, Org. Lett., 2014, 16, 1144-1147.

DOI: 10.1021/ol500003g (free Supporting Information)


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Abstract

Pd-catalyzed cross-coupling reaction of acylindium reagents generated in situ from easily available acid chlorides and indium with aryl iodides, triflates and alkenyl triflate enables a reversed-polarity synthesis of various unsymmetric aryl aryl and alkenyl aryl ketones.


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Key Words

aryl ketones, indium


ID: J54-Y2014