Intermolecular Hydroamination of 1,3-Dienes Catalyzed by Bis(phosphine)carbodicarbene-Rhodium Complexes
Matthew J. Goldfogel, Courtney C. Roberts and Simon J. Meek*
*Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States, Email: sjmeekunc.edu
M. J. Goldfogel, C. C. Roberts, S. J. Meek, J. Am. Chem. Soc., 2014, 136, 6227-6230.
DOI: 10.1021/ja502275w (free Supporting Information)
The use of a carbodicarbene-based pincer ligand scaffold enables a site-selective Rh(I)-catalyzed intermolecular hydroamination of 1,3-dienes with aryl and alkyl amines. Transformations proceed in the presence of 1.0-5.0 mol % Rh complex at 35 - 120 °C; allylic amines are obtained in up to 97% yield and with >98:2 site selectivity.
see article for more examples