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Mild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents

Chi Wai Cheung, Peng Ren and Xile Hu*

*Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytecnique Fédérale de Lausanne (EPFL), ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland, Email:

C. W. Cheung, P. Ren, X. Hu, Org. Lett., 2014, 16, 2566-2569.

DOI: 10.1021/ol501087m (free Supporting Information)


A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature tolerates a wide range of secondary alkyl halides and terminal alkynes to afford substituted alkynes in good yields.

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ID: J54-Y2014