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Imino Glycals via Ruthenium-Catalyzed RCM and Isomerization

Bernd Schmidt*, Sylvia Hauke, Nino Mühlenberg

*Universität Potsdam, Institut für Chemie (Organische Synthesechemie), Karl-Liebknecht-Straße 24-25, 14476 Potsdam-Golm, Germany, Email: bernd.schmidtuni-potsdam.de

B. Schmidt, S. Hauke, N. Mühlenberg, Synthesis, 2014, 46, 1648-1658.

DOI: 10.1055/s-0033-1338615 (free Supporting Information)


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Abstract

In situ transformation of a metathesis active Ru-carbene into an isomerization active Ru-hydride catalyst by addition of hydroxide as a chemical trigger enables the conversion of N-Allyl-N-homoallylamines in one step into cyclic enamides via a tandem catalytic ring-closing metathesis-isomerization sequence.

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An Olefin Metathesis/Double Bond Isomerization Sequence Catalyzed by an In Situ Generated Ruthenium Hydride Species

B. Schmidt, Eur. J. Org. Chem., 2003, 816-819.


Key Words

N-heterocycles, isomerization, ring closing metathesis, ruthenium, tandem reaction


ID: J66-Y2014