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Preparation of Unsymmetrical Ketones from Tosylhydrazones and Aromatic Aldehydes via Formyl C-H Bond Insertion

Daniel M. Allwood*, David C. Blakemore and Steven V. Ley

*Department of Biosciences and Chemistry, City Campus, Howard Street, Sheffield, S1 1WB, United Kingdom, Email: D.Allwoodshu.ac.uk

D. M. Allwood, D. C. Blakemore, S. V. Ley, Org. Lett., 2014, 16, 3064-3067.

DOI: 10.1021/ol5011714 (free Supporting Information)


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Abstract

A convenient procedure for the synthesis of unsymmetrical ketones from bench-stable tosylhydrazones and aryl aldehydes can be performed in one pot from the parent carbonyl compound and needs only a base without additional promoters.

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Key Words

carbonyl compounds


ID: J54-Y2014