Selective Reduction of Halogenated Nitroarenes with Hydrazine Hydrate in the Presence of Pd/C
Fang Li, Brendan Frett, Hong-yu Li*
*College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85721, USA, Email: hongyulipharmacy.arizona.edu
F. Li, B. Frett, H.-y Li, Synlett, 2014, 25, 1403-1408.
DOI: 10.1055/s-0033-1339025
see article for more reactions
Abstract
Several bromo, chloro, iodo and multihalogenated nitroarenes have been selectively reduced with hydrazine hydrate in the presence of Pd/C to give the corresponding halogenated anilines in good yield. Using microwave irradiation at elevated temperature and pressure, dehalogenated products can be isolated.
see article for more examples
Key Words
reduction of nitro compounds, hydrazine hydrate, palladium on carbon, aromatic amines, transfer hydrogenation
ID: J60-Y2014