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Metal-Free, Efficient Oxyfluorination of Olefins for the Synthesis of α-Fluoroketones

Qiang Yang, Liu-Liang Mao, Bin Yang and Shang-Dong Yang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. Chinan, Email: yangshdlzu.edu.cn

Q. Yang, L.-L. Mao, B. Yang, S.-D. Yang, Org. Lett., 2014, 16, 3460-3463.

DOI: 10.1021/ol501357w (free Supporting Information)


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Abstract

A metal-free and green catalytic system enables an oxyfluorination of olefins for the synthesis of α-fluoroketones which is an important building block for organic synthesis. Moreover, this reaction system exhibits great functional group tolerance.

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Key Words

Fluorination, Benzylic Oxidation, Selectluor, Oxygen, IBX


ID: J54-Y2014