Organic Chemistry Portal

Abstracts

Search:

Decarboxylative Thioamidation of Arylacetic and Cinnamic Acids: A New Approach to Thioamides

Tirumaleswararao Guntreddi, Rajeshwer Vanjari and Krishna Nand Singh*

*Department of Chemistry (Centre of Advanced Study), Faculty of Science, Banaras Hindu University, Varanasi 221005, India, Email: knsinghbhu.ac.in

T. Guntreddi, R. Vanjari, K. N. Singh, Org. Lett., 2014, 16, 3624-3625.

DOI: 10.1021/ol501482g (free Supporting Information)



see article for more reactions

Abstract

A decarboxylative strategy for the synthesis of thioamides involves a three-component reaction of arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant.

see article for more examples



Key Words

thionation, amination, multicomponent reactions


ID: J54-Y2014