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Sonogashira Couplings Catalyzed by Collaborative (N-Heterocyclic Carbene)-Copper and -Palladium Complexes

Christopher W. D. Gallop, Ming-Tsz Chen and Oscar Navarro*

*Department of Chemistry, University of Sussex, Brighton BN1 9QJ, United Kingdom, Email: o.navarrosussex.ac.uk

C. W. D. Gallop, M.-T. Chen, O. Navarro, Org. Lett., 2014, 16, 3724-3727.

DOI: 10.1021/ol501540w  (free Supporting Information)


Abstract

Catalyst loadings of 1 mol % (NHC)-Cu and 0.01 mol % (NHC)-Pd complexes enable a general protocol for Sonogashira coupling of aryl bromides and aryl alkynes, in air and in a non-anhydrous solvent, in high yields.

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Key Words

Sonogashira Coupling


ID: J54-Y2014