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Stereoretentive Pd-Catalyzed Kumada-Corriu Couplings of Alkenyl Halides at Room Temperature

Arkady L. Krasovskiy, Stephen Haley, Karl Voigtritter and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu

A. L. Krasovskiy, S. Haley, K. Voigtritter, B. H. Lipshutz, Org. Lett., 2014, 16, 4066-4069.

DOI: 10.1021/ol501535w  (free Supporting Information)



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Abstract

A new combination of reagents enables a stereoselective palladium-catalyzed Kumada-Corriu reactions of functionalized alkenyl halides and a variety of Grignard reagents, including those bearing β-hydrogen atoms and sensitive functional groups, at room temperature.

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Key Words

Kumada Coupling, Alkenylation


ID: J54-Y2014