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2-Pyridonate Tantalum Complexes for the Intermolecular Hydroaminoalkylation of Sterically Demanding Alkenes

Eugene Chong, Jason W. Brandt and Laurel L. Schafer*

*Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1, Email: schaferchem.ubc.ca

E. Chong, J. W. Brandt, L. L. Schafer, J. Am. Chem. Soc., 2014, 136, 10898-10901.

DOI: 10.1021/ja506187m


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Abstract

A mixed 2-pyridonate-Ta(NMe2)3Cl complex catalyzes a direct C-H alkylation adjacent to nitrogen in unprotected secondary amines. The hydroaminoalkylation of sterically demanding internal alkenes to yield α-alkylated amines provides a direct, atom-economic formation of C(sp3)-C(sp3) bonds.

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Key Words

amines


ID: J48-Y2014