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[Bmim]PF6-Promoted Ligandless Suzuki-Miyaura Coupling Reaction of Potassium Aryltrifluoroborates in Water

Leifang Liu*, Yan Dong, Bo Pang and Jiahai Ma

*Key Laboratory of Coordination Chemistry and Functional Materials in Universities of Shandong, Dezhou University, Dezhou 253023, People’s Republic of China, Email: orgllf163.com

L. Liu, Y. Dong, B. Pang, J. Ma, J. Org. Chem., 2014, 79, 7193-7198.

DOI: 10.1021/jo500840s (free Supporting Information)


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Abstract

The Suzuki-Miyaura coupling of potassium aryltrifluoroborates with aryl bromides in water is promoted by [bmim]PF6 using Pd(OAc)2 as a catalyst and Na2CO3 as a base under air. The efficiency of the catalytic system depends on the quantity of [bmim]PF6. A wide range of biaryls and polyaryls can be easily prepared in very good yields.

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Key Words

Suzuki Coupling, Biaryl Synthesis


ID: J42-Y2014