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Photocatalytic Decarboxylative Reduction of Carboxylic Acids and Its Application in Asymmetric Synthesis

Carlo Cassani, Giulia Bergonzini and Carl-Johan Wallentin*

*Department of Chemistry and Molecular Biology, Gothenburg University, SE-412 58, Gothenburg, Sweden, Email: carl.wallentinchem.gu.se

C. Cassani, G. Bergonzini, C.-J. Wallentin, Org. Lett., 2014, 16, 4228-4231.

DOI: 10.1021/ol5019294  (free Supporting Information)


Abstract

A mild decarboxylative reduction of naturally abundant carboxylic acids such as α-amino acids and α-hydroxy acids has been achieved via visible-light photoredox catalysis using an organocatalytic photoredox system. This method allows the synthesis of high-value compounds including medicinally relevant scaffolds and a monodecarboxylation of differently substituted dicarboxylic acids.


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Key Words

decarboxylation


ID: J54-Y2014