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Metal-Free: A Novel and Efficient Aerobic Oxidation of Primary Amines to Oximes Using N,N′,N″-Trihydroxyisocyanuric Acid and Acetaldoxime as Catalysts in Water

Jiatao Yu, Ming Lu*

*School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Road, Nanjing 210094, P. R. of China, Email: lumingnjust163.com

J. Yu, M. Lu, Synlett, 2014, 25, 1873-1878.

DOI: 10.1055/s-0033-1338646 (free Supporting Information)


Abstract

A general, efficient, and metal-free method for aerobic oxidation of primary benzylamines to the corresponding oximes in good yields is catalyzed by N,N′,N″-trihydroxyisocyanuric acid in the presence of acetaldoxime and water as solvent. This practical method uses air as economic and green oxidant, water as green solvent, and tolerates a wide range of substrates.

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Key Words

amines, catalysis, hydrogen transfer, oxygen, oxidation, oximes, green chemistry


ID: J60-Y2014