One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone-Alkyne Cycloaddition Reaction
Simon Specklin, Elodie Decuypere, Lucie Plougastel, Soifia Aliani and Frédéric Taran*
*CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage,
Gif sur Yvette, F-91191, France, Email: frederic.taran
cea.fr
S. Specklin, E. Decuypere, L. Plougastel, S. Aliani, F. Taran, J. Org. Chem., 2014, 79, 7772-7777.
DOI: 10.1021/jo501420r
Abstract
A copper-catalyzed sydnone-alkyne cycloaddition reaction offers a robust, straightforward and general method for constructing 1,4-pyrazoles from arylglycines using a three-step one-pot procedure.
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Key Words
ID: J42-Y2014
