Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides
Gaobo Hu, Yuxing Gao* and Yufen Zhao
*Department of Chemistry and Key Laboratory for Chemical
Biology of Fujian Province, College of Chemistry and Chemical Engineering,
Xiamen University, Xiamen 361005, Fujian, China, Email: gaoxingchem
xmu.edu.cn
G. Hu, Y. Gao, Y. Zhao, Org. Lett., 2014, 16, 4464-4467.
DOI: 10.1021/ol502009b
Abstract
In a decarboxylative cross-coupling of alkynyl acids in the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and absolute stereoselectivity.
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Key Words
ID: J54-Y2014
