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A New Iron(III)-Salen Catalyst for Enantioselective Conia-ene Carbocyclization

Subrata Shaw and James D. White*

*Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States, Email: James.whiteoregonstate.edu

S. Shaw, J. D. White, J. Am. Chem. Soc., 2014, 136, 13174-13177.

DOI: 10.1021/ja507853f (free Supporting Information)


Abstract

A chiral iron(III)-salen complex catalyzes an asymmetric Conia-ene-type cyclization of α-functionalized ketones containing an unactivated terminal alkyne and produces an exo-methylenecyclopentane scaffold possessing a stereodefined quaternary center.

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Key Words

Conia-ene reaction, Cyclopentanes


ID: J48-Y2014