A Highly Efficient Synthesis of 2,5-Disubstituted Furans from Enyne Acetates Catalyzed by Lewis Acid and Palladium

Zheng-Wang Chen*, Miao-Ting Luo, Yue-Lu Wen, Min Ye, Zhong-Gao Zhou, Liang-Xian Liu

*School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi, 341000, P. R. of China, Email: chenzwanggnnu.cn

Z.-W. Chen, M.-T. Luo, Y.-L. Wen, M. Ye, Z.-G. Zhou, L.-X. Liu, Synlett, 2014, 25, 2341-2344.

DOI: 10.1055/s-0034-1379213

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Abstract

Palladium catalysis enables a highly efficient synthesis of a wide range of 2,5-disubstituted furans in very good yields from enyne acetates in the presence of a Lewis acid.

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Synthesis of 2,5-Disubstituted 3-Iodofurans via Palladium-Catalyzed Coupling and Iodocyclization of Terminal Alkynes

Z. Chen. G. Huang, H. Jiang, H. Huang, X. Pan, J. Org. Chem., 2011, 76, 1134-1139.

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Key Words

furans, enyne acetates, Lewis acid, palladium

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ID: J60-Y2014