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Copper-Catalyzed Direct Amidation of Heterocycles with N-Fluorobenzenesulfonimide

Sichang Wang, Zhangqin Ni, Xin Huang, Jichao Wang and Yuanjiang Pan*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, People’s Republic of China, Email: panyuangjiangzju.edu.cn

S. Wang, Z. Ni, X. Huang, J. Wang, Y. Pan, Org. Lett., 2014, 16, 5648-5651.

DOI: 10.1021/ol502724u (free Supporting Information)


Abstract

A highly efficient amidation reaction of heterocycles with N-fluorobenzenesulfonimide (NFSI) presumably proceedes via C-H bond activation in the presence of cuprous iodide as catalyst. Various α-amidated heterocycle derivatives have been generated in good to excellent yields.

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Key Words

thiophenes, furans, pyrroles


ID: J54-Y2014