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A Novel Approach for the Synthesis of Biologically Important N-Aryl Amides with Arenediazonium Salts

Jeevan Manohar Bhojane, Vilas Gangadhar Jadhav, Jayashree Milind Nagarkar*

*Department of Chemistry, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai 400 019, India, Email: jm.nagarkarictmumbai.edu.in

J. M. Bhojane, V. G. Jadhav, J. M. Nagarkar, Synthesis, 2014, 46, 2951-2956.

DOI: 10.1055/s-0034-1378556 (free Supporting Information)


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Abstract

Inexpensive copper(I) iodide catalyzes the formation of N-aryl amides from arenediazonium salts and primary amides via in situ formation of iodoarenes in the presence of tetrabutylammonium iodide. This protocol is applicable to various substituted amides and diazonium salts, giving very good yields of the desired products.


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Key Words

arylations, diazonium compounds, amides, catalysis, copper


ID: J66-Y2014