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α-Alkylation of Ketones with Primary Alcohols Catalyzed by a Cp*Ir Complex Bearing a Functional Bipyridonate Ligand

Feng Li*, Juan Ma and Nana Wang

*Key Laboratory for Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, People’s Republic of China, Email: fenglinjust.edu.cn

F. Li, J. Ma, N. Wang, J. Org. Chem., 2014, 79, 10447-10455.

DOI: 10.1021/jo502051d (free Supporting Information)


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Abstract

A Cp*Ir complex bearing a functional bipyridonate ligand is a highly effective and versatile catalyst for the α-alkylation of ketones with primary alcohols under environmentally benign and mild conditions. Furthermore, this complex also exhibited a high level of catalytic activity for the α-methylation of ketones with methanol.

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Key Words

α-alkylation, green chemistry


ID: J42-Y2014