Biscarboxy-Functionalized Imidazole and Palladium as Highly Active Catalytic System in Protic Solvents: Methanol and Water
Regina Martínez, Isidro M. Pastor*, Miguel Yus*
*Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain, Email: ipastorua.es, yusua.es
R. Martínez, I. M. Pastor, M. Yus, Synthesis, 2014, 46, 2965-2975.
DOI: 10.1055/s-0034-1378552
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Abstract
An in situ generated palladium complex obtained from palladium(II) acetate (0.1 mol%) and 1,3-bis(carboxymethyl)imidazole (0.2 mol%) is very active for Suzuki couplings in protic solvents, especially in methanol. Biaryl and styrene derivatives have been prepared in good isolated yields.
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Key Words
palladium, organometallic reagents, heterocycles, solvent effects, cross-coupling, Suzuki coupling
ID: J66-Y2014