Transition Metal-Mediated C=O and C=C Bond-Forming Reactions: A Regioselective Strategy for the Synthesis of Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrazines
Hua Cao*, Xiaohang Liu, Jinqiang Liao, Jianping Huang, Huifang Qiu, Qinlin Chen and Yaoyi Chen
*School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China, Email: caohuagdpu.edu.cn
H. Cao, X. Liu, J. Liaou, J. Huang, H. Qiu, Q. Chen, Y. Chen, J. Org. Chem., 2014, 79, 11209-11214.
DOI: 10.1021/jo501671x
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Abstract
Copper(I)- and palladium(II)-catalyzed cyclizations enable a convenient synthesis of functionalized imidazo[1,2-a]pyridine aldehydes/ketones and 3-vinyl imidazo[1,2-a]pyridines. These one-pot reactions proceed smoothly with commercially available catalysts and afford the products in good yields.
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Key Words
ID: J42-Y2014