Three-Component Reaction between Isocyanides, Aliphatic Amines and Elemental Sulfur: Preparation of Thioureas under Mild Conditions with Complete Atom Economy

Thanh Binh Nguyen*, Ludmila Ermolenko, Ali Al-Mourabit*

*Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, CNRS, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France, Spain, Email: nguyenicsn.cnrs-gif.fr, ali.almourabitcnrs.fr

T. B. Nguyen, L. Ermolenko, A. Al-Mourabit, Synthesis, 2014, 46, 3172-3179.

DOI: 10.1055/s-0034-1379327

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Abstract

A completely atom-economic reaction of isocyanides with aliphatic amines in the presence of elemental sulfur proceeds efficiently at (nearly) ambient temperature to produce thioureas in excellent yields.

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Key Words

multicomponent reactions, elemental sulfur, isocyanides, thioureas (thionation, amination), atom economy, sulfur-amine interaction

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ID: J66-Y2014