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Cyanation of Unactivated Aryl Chlorides and Aryl Mesylates Catalyzed by Palladium and Hemilabile MOP-Type Ligands

Yahui Tu, Yi Zhang, Sheng Xu, Zhaoguo Zhang, Xiaomin Xie*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. of China, Email: xiaominxiesjtu.edu.cn

Y. Tu, Y. Zhang, S. Xu, Z. Zhang, X. Xie, Synlett, 2014, 25, 2938-2942.

DOI: 10.1055/s-0034-1379483 (free Supporting Information)


Abstract

Hemilabile, bulky, and electron-rich MOP-type ligands enable a highly efficient palladium-catalyzed cyanation of unactivated aryl chlorides and even aryl mesylates with potassium hexacyanoferrate in good yields using t-BuOH and H2O as the solvent and K2CO3 as the base.

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Key Words

palladium, monophosphine ligands, cyanation, aryl chlorides, aryl mesylates


ID: J60-Y2014