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Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media

Daniel T. Cohen and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu

D. T. Cohen, S. L. Buchwald, Org. Lett., 2015, 17, 202-205.

DOI: 10.1021/ol5032359 (free Supporting Information)


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Abstract

A mild and efficient, palladium-catalyzed reaction allows the cyanation of a wide range of (hetero)aryl halides and triflates at low catalyst loadings with mild temperatures ranging from rt to 40 C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.

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Key Words

cyanation


ID: J54-Y2015