Copper-Mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide

Xinjin Li, Jingwei Zhao, Liang Zhang, Mingyou Hu, Limin Wang* and Jinbo Hu*

*East China University of Science and Technology, 130 Meilong Road; Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China, Email: wangliminecust.edu.cn, jinbohusioc.ac.cn

X. Li, J. Zhao, L. Zhang, M. Hu, L. Wang, J. Hu, Org. Lett., 2015, 17, 298-301.

DOI: 10.1021/ol5034018

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Abstract

Trifluoromethylcopper (“CuCF₃”) species can be generated from readily available phenyl trifluoromethyl sulfoxide. The reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands. Furthermore, the “CuCF₃” species can also undergo oxidative cross-coupling with terminal alkynes and arylboronic acids.

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Key Words

trifluoromethylation

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ID: J54-Y2015