Palladium-Catalyzed α-Arylation of Aryl Acetic Acid Derivatives via Dienolate Intermediates with Aryl Chlorides and Bromides
Sheng-Chun Sha, Jiadi Zhang and Patrick J. Walsh*
*Roy and Diana Vagelos Laboratories, Department of Chemistry,
University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania
19104-6323, United States, Email: pwalsh
sas.upenn.edu
S.-C. Sha, J. Zhang, P. J. Walsh, Org. Lett., 2015, 17, 410-413.
DOI: 10.1021/ol503545j
see article for more reactions
Abstract
A palladium-catalyzed deprotonative cross-coupling process (DCCP) enables a γ-arylation of aryl acetic acids with wide range of aryl bromides and chlorides. A procedure for the palladium-catalyzed α-arylation of styryl acetic acids is also described.
see article for more examples
Key Words
ID: J54-Y2015
