Organic Chemistry Portal

Abstracts

Search:

Cu-Catalyzed Aerobic Oxidative Esterification of Acetophenones with Alcohols to α-Ketoesters

Xuezhao Xu, Wen Ding, Yuanguang Lin and Qiuling Song*

*Institute of Next Generation Matter Transformation, College of Chemical Engineering, Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China, Email: qsonghqu.edu.cn

X. Xu, W. Ding, Y. Lin, Q. Song, Org. Lett., 2015, 17, 516-519.

DOI: 10.1021/ol503472x (free Supporting Information)


Abstract

Copper-catalyzed aerobic oxidative esterification of acetophenones with alcohols using molecular oxygen gives a broad range of α-ketoesters in good yields. Mechanism studies evealed that the carbonyl oxygen in the ester mainly originated from dioxygen.


see article for more examples



Key Words

oxidative esterification, α-keto esters, oxygen


ID: J54-Y2015