PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols
Teppei Fujimoto and Tobias Ritter*
*Department of Chemistry and Chemical Biology, Harvard
University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States, Email:
ritter
chemistry.harvard.edu
T. Fujimoto, T. Ritter, Org. Lett., 2015, 17, 544-547.
DOI: 10.1021/ol5035518
Abstract
PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. The reagent can be used for the deoxyfluorination of various phenols and heterocycles.
see article for more examples
P. Tang, W. Wang, T. Ritter, J. Am. Chem. Soc., 2011, 133, 11482-11484.
Key Words
ID: J54-Y2015
