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Microwave-Assisted Catalyst-Free Synthesis of Substituted 1,2,4-Triazoles

Ganesh M. Shelke, V. Kameswara Rao, Mukund Jha, T. Stan Cameron, Anil Kumar*

*Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333 031, India, Email: anilkumarpilani.bits-pilani.ac.in

G. M. Shelke, V. K. Rao, M. Jha, T. S. Cameron, A. Kumar, Synlett, 2015, 26, 404-407.

DOI: 10.1055/s-0034-1379734 (free Supporting Information)


Abstract

A simple, efficient, and mild method for the synthesis of substituted 1,2,4-triazoles from hydrazines and formamide proceeds smoothly under microwave irradiation in the absence of a catalyst and shows excellent functional-group tolerance.

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Key Words

microwave, microwave-assisted organic synthesis, 1,2,4-triazoles, aryl hydrazines, formamide


ID: J60-Y2015