Alkyne Hydroacylation: Switching Regioselectivity by Tandem Ruthenium Catalysis
Qing-An Chen, Faben A. Cruz and Vy M. Dong*
*Department of Chemistry, University of California-Irvine,
4403 Natural Sciences 1, Irvine, California 92697, United States, Email: dongv
uci.edu
Q.-A. Chen, F. A. Cruz, V. M. Dong, J. Am. Chem. Soc., 2015, 137, 3157-3160.
DOI: 10.1021/ja512015w
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Abstract
Tandem Ru-catalysis enables the coupling of internal alkynes with aldehydes for the synthesis of β,γ-unsaturated ketones with high regioselectivity. The catalyst for example differentiates between methyl and ethyl substituent on the alkyne.
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Key Words
ID: J48-Y2015
