Ligand-Free, Palladium-Catalyzed Dihydrogen Generation from TMDS: Dehalogenation of Aryl Halides on Water
Anish Bhattacharjya, Piyatida Klumphu and Bruce H. Lipshutz*
*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States, Email: lipshutzchem.ucsb.edu
A. Bhattacharjya, P. Klumphu, B. H. Lipshutz, Org. Lett., 2015, 17, 1122-1125.
DOI: 10.1021/ol5037369 (free Supporting Information)
see article for more reactions
Nanoparticles formed from PdCl2 in the presence of tetramethyldisiloxane (TMDS) on water enable a mild and environmentally attractive dehalogenation of functionalized aryl halides. The reaction medium with the catalyst can be recycled.
see article for more examples