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Indium(III)-Catalyzed Knoevenagel Condensation of Aldehydes and Activated Methylenes Using Acetic Anhydride as a Promoter

Yohei Ogiwara, Keita Takahashi, Takefumi Kitazawa and Norio Sakai*

*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan, Email: sakachemrs.noda.tus.ac.jp

Y. Ogiwara, K. Takahashi, T. Kitazawa, N. Sakai, J. Org. Chem., 2015, 80, 3101-3110.

DOI: 10.1021/acs.joc.5b00011 (free Supporting Information)


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Abstract

The combination of a catalytic amount of InCl3 and acetic anhydride remarkably promotes the Knoevenagel condensation of a variety of aldehydes and activated methylene compounds via the formation of a geminal diacetate intermediate.

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Key Words

Knoevenagel Condensation


ID: J42-Y2015