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Synthesis of Vinyl Boronates from Aldehydes by a Practical Boron-Wittig Reaction

John R. Coombs, Liang Zhang and James P. Morken*

*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States, Email: morkenbc.edu

J. R. Coombs, L. Zhang, J. P. Morken, Org. Lett., 2015, 17, 1708-1711.

DOI: 10.1021/acs.orglett.5b00480 (free Supporting Information)


Abstract

A highly stereoselective boron-Wittig reaction between stable and readily accessible 1,1-bis(pinacolboronates) and aldehydes furnishes various synthetically useful di- and trisubstituted vinyl boronate esters.

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Key Words

Wittig Reaction, vinylboronates


ID: J54-Y2015