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Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines

Erhad Ascic and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu

E. Ascic, S. L. Buchwald, J. Am. Chem. Soc., 2015, 137, 4666-4669.

DOI: 10.1021/jacs.5b02316 (free Supporting Information)


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Abstract

A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines offers mild reaction conditions and high degree of functional group compatibility. This method is highly valuable for the synthesis various cis-2,3-disubstituted indolines in high yield and enantioselectivity.

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Key Words

indolines, DEMS, CuH


ID: J48-Y2015